Treatment options
Compounded semaglutide vs tirzepatide: what's the difference?
The short answer
The main difference is that semaglutide acts on one receptor pathway (GLP‑1) and tirzepatide acts on two (GIP and GLP‑1). Zenbody offers both, compounded, as a weekly injection or a daily tablet, and which one you get, if any, is up to a licensed clinician who reviews your health history.
Side by side
| Semaglutide | Tirzepatide | |
|---|---|---|
| Receptor pathways | GLP‑1 | GIP and GLP‑1 |
| Forms at Zenbody | Weekly injection or daily tablet | Weekly injection or daily tablet |
| Injection price | $149 first month, then $249/mo | $179 first month, then $299/mo |
| Tablet price | $199 first month, then $299/mo | $299 first month, then $349/mo |
| Injection supply | 1 mL vial · 4-week supply | 2 mL vial · 4-week supply |
| Tablet supply | 30-day supply · 30 tablets | 30-day supply · 30 tablets |
How the choice gets made
In the assessment you can tell us which one you’re leaning toward. From there the clinician takes over. They’ll look at your history, what else you take, and whether you’ve been on a GLP‑1 before, then decide if either is appropriate, which one, and the starting dose.
We don’t claim one works better for everyone. They’re two different medicines, and the better fit depends on the person.
How the price compares
After month one, tirzepatide is $50 a month more than semaglutide in the same form. Dose changes won’t move either price, and both include your clinician, the medication and shipping.
Side effects
Side effects are possible with either one. Nausea, vomiting, diarrhea, constipation and stomach pain are the common ones, and serious side effects can occur as well. Ask your clinician anything, read the safety information that comes with your medication, and know when to get help right away.
Not sure which one you’d get? That’s what the review is for. Start your assessment. If you’re not approved, you’re fully refunded.
Common questions
Which one is stronger?
Stronger isn’t really the right word. These are two different medicines. Your clinician picks the one that fits you, and the dose.
Can I switch from semaglutide to tirzepatide later?
Message your clinician. If they decide a change is right, you’re billed for the new treatment the day you switch, and your new monthly cycle starts that day.
Are these brand-name medications?
No. Compounded semaglutide and tirzepatide are different products, and they aren’t FDA-approved.
Sources
- Compounded Semaglutide Online. Zenbody.
- Compounded Tirzepatide Online. Zenbody.
- Semaglutide injection: MedlinePlus drug information. U.S. National Library of Medicine. Side effects of FDA-approved semaglutide injection products. Last revised May 15, 2026.
- Tirzepatide injection: MedlinePlus drug information. U.S. National Library of Medicine. Side effects of FDA-approved tirzepatide injection products. Last revised February 15, 2026.
About this answer
- Written by
- Zenbody
- First published
- Facts last checked
Prices on this page come from the same source as our semaglutide and tirzepatide pages, so they always match. This is general information, not medical advice; whether a treatment is right for you is a licensed clinician's decision. Something out of date? Tell us at support@zenbody.com.